Will exogenous surfactant treat respiratory distress syndrome?
نویسنده
چکیده
منابع مشابه
An update on clinical surfactant preparations and respiratory disease
The pulmonary surfactant and respiratory disease are tightly linked. Adequate surfactant activity remains critical for optimal lung function throughout life, and secondary surfactant dysfunction may contribute to the process of many lung diseases, including Acute Respiratory Distress Syndrome, asthma, cystic fibrosis and pneumonia among others. Attempts to treat these lung diseases with exogeno...
متن کاملThe future of exogenous surfactant therapy.
Since the identification of surfactant deficiency as the putative cause of the infant respiratory distress syndrome (RDS) by Avery and Mead in 1959, our understanding of the role of pulmonary surfactant in respiratory physiology and the pathophysiology of acute lung injury (ALI) has advanced substantially. Surfactant replacement has become routine for the prevention and treatment of infant RDS...
متن کاملSurfactant replacement therapy in the neonate: beyond respiratory distress syndrome.
Surfactant-replacement therapy is a life-saving treatment for preterm infants with respiratory distress syndrome, a disorder characterized by surfactant deficiency. Repletion with exogenous surfactant decreases mortality and thoracic air leaks and is a standard practice in the developed world. In addition to respiratory distress syndrome, other neonatal respiratory disorders are characterized b...
متن کاملNatural surfactant substitution in respiratory distress syndrome.
Natural surfactants consist of unique proteins and lipids. Their effectiveness in improving subnormal lung function in surfactant deficiency should be established prior to any clinical trials. Rigorous tests are required to document batch to batch variability in surface activity and to exclude toxic contaminants. Up to this date randomized clinical trials in small preterm infants have demonstra...
متن کاملBrief Reports Surfactant Therapy in Neonatal Respiratory Distress Syndrome
Respiratory distress syndrome (RDS) is the leading cause of neonatal respiratory distress in our country and is the commonest disorder requiring assisted ventilation all over the world(l,2), Exogenous surfactant administration is now an established mode of therapy in neonatal RDS (hyaline membrane disease, HMD). Ever since the first report of successful surfactant replacement therapy in neonate...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 58 5 شماره
صفحات -
تاریخ انتشار 1983